Calcium channel risk allele associated with executive function in bipolar disorder By Lucy Piper, Senior medwireNews Reporter Experts have found an allele in a voltage-gated calcium gene that is associated with an elevated risk for poor executive function in sufferers with bipolar disorder . They report that individuals with BD holding the Met/Met genotype of the one nucleotide polymorphism rs1006737 in the a1-C subunit of the L-type voltage-gated calcium channel gene had even worse executive function than those having the Val/Val genotype. This was no matter manic or depressive symptoms, they note. Also, no aftereffect of this allele on executive function was observed in healthy controls.This represents a loss of around 19 percent from the same period in 2013 and was mainly because of the August 2013 expiration of the proper to receive earn-out obligations on Santyl partially offset by elevated XIAFLEX royalties and the mark-up on price of goods sold income. June 30 Royalty and mark-up on price of items sold for the next one fourth ended, 2014 had been $2.6 million, in comparison to royalty, mark-up on cost of goods sold, and earn-out revenues of $3.2 million for the same period in 2013. Royalty and mark-up on price of products sold revenues known under BioSpecifics' contract with Auxilium Pharmaceuticals, Inc. for the next quarter ended June 30, 2014 had been $2.6 million, in comparison to $1.7 million for the same period in 2013. This represents a rise of around 53 percent from the same period in 2013.