Calcium channel risk allele associated with executive function in bipolar disorder By Lucy Piper.

Calcium channel risk allele associated with executive function in bipolar disorder By Lucy Piper, Senior medwireNews Reporter Experts have found an allele in a voltage-gated calcium gene that is associated with an elevated risk for poor executive function in sufferers with bipolar disorder . They report that individuals with BD holding the Met/Met genotype of the one nucleotide polymorphism rs1006737 in the a1-C subunit of the L-type voltage-gated calcium channel gene had even worse executive function than those having the Val/Val genotype. This was no matter manic or depressive symptoms, they note. Also, no aftereffect of this allele on executive function was observed in healthy controls.This represents a loss of around 19 percent from the same period in 2013 and was mainly because of the August 2013 expiration of the proper to receive earn-out obligations on Santyl partially offset by elevated XIAFLEX royalties and the mark-up on price of goods sold income. June 30 Royalty and mark-up on price of items sold for the next one fourth ended, 2014 had been $2.6 million, in comparison to royalty, mark-up on cost of goods sold, and earn-out revenues of $3.2 million for the same period in 2013. Royalty and mark-up on price of products sold revenues known under BioSpecifics' contract with Auxilium Pharmaceuticals, Inc. for the next quarter ended June 30, 2014 had been $2.6 million, in comparison to $1.7 million for the same period in 2013. This represents a rise of around 53 percent from the same period in 2013.