The results, to be published within an upcoming issue of NeuroImage, suggest that clinical interventions designed to strengthen these inhibitory responses could help cocaine abusers prevent using drugs and avoid relapse. Exposure to drugs or stimuli connected with using drugs is one of the most common elements resulting in relapse in drug-addicted individuals, stated Nora Volkow, Director of the National Institute on SUBSTANCE ABUSE and lead author on the paper. We realize from previous research that drug cues can result in dramatic changes in the brain that are linked to a strong craving response, added co-author Gene-Jack Wang, Seat of Brookhaven’s medical section. This study supplies the first proof that cocaine abusers retain some capability to cognitively inhibit their craving responses to drug-related cues.This open-label Phase 4 study is evaluating 51 individuals who got recurrence of a contracture in a joint that were previously efficiently treated with XIAFLEX . Individuals had been treated with up to three shots of XIAFLEX to the recurrent cord and had been after that evaluated for clinical result, adjustments in contracture and flexibility, physician evaluation of improvement, patient safety and satisfaction. This interim evaluation was conducted in the end individuals had completed their 30-day follow-up assessments. Tursi, M.D., Chief Medical Officer of Auxilium. Dupuytren's contracture is a chronically progressive disorder where as many as half of sufferers previously treated ultimately suffer recurrence of disease.