The ongoing work was carried out by Elisa Panzarini, as part of his Post Doctoral analysis, working with Luciana Dini and various other colleagues, at the University of Salento, Department of Biological and Environmental Research and Technology, Lecce, Italy. Dr. Dini stated Taking into account that innate immunity is founded on macrophage phagocytosis of non-self microrganisms and particles, the exposure to SMF could interfere with a correct immune response. Certainly, phagocytosis of apoptotic cells represents the finish point of apoptosis, permitting the fast removal of lifeless cells simply by macrophages and neighbours.‘Therefore, increasing the demand for creation capacity at least by four times a lot more than the existing capability. This may be essential to keep up with the demand-supply equilibrium.’ This creates an urgent need for alternate manufacturing media such as for example transgenic plants and pets, besides the microbial and mammalian and fungal cell culture systems. Fungal cell lines provide considerable time and cost benefits over mammalian cell lines. For example, the latter proves to be a lengthy process and could alter the properties of the final therapeutic glycoprotein.