More than 300,000 people in North America are affected, but the mechanism of irregular muscle constrictions is not well understood. Here, Japanese research group led by Prof Atsushi Nambu and Dr Satomi Chiken of National Institute for Physiological Sciences in Japan, with Dr. Pullanipally Shashidharan of Mt Sinai College of Medication in USA, has found that the reduced activity of the basal ganglia, part of the brain structure, is the main cause of abnormal muscle constrictions of dystonia utilizing a mouse model. They report their results in Journal of Neuroscience , on Dec 17, 2008. Related StoriesUsing the butterfly effect to predict cardiovascular disease: an interview with Dr George and Dr Parthimos, Cardiff UniversityExercise and chronic fatigue syndrome: an interview with Professor Trudie ChalderProtein sensor for proprioception foundThey investigated neuronal activity in the basal ganglia of a dystonia mouse model, which was generated by transferring individual dystonia genes, in awake state.Professor Jack Cuzick, Queen Mary University of London, comments: It has long been known that aspirin – one of the cheapest & most common drugs on the market – can drive back certain types of malignancy. But until our research, where we analysed all of the available evidence, it had been unclear whether the benefits of acquiring aspirin outweighed the disadvantages. Whilst there are some serious unwanted effects that can’t be ignored, acquiring aspirin daily looks to end up being the most crucial thing we can do to reduce cancer tumor after stopping smoking cigarettes and reducing obesity, and will probably be easier to implement. Our study shows that if everyone aged between 50-65 started taking aspirin daily for at least a decade, there would be a 9 percent reduction in the number of cancers, strokes and center attacks overall in males and around 7 percent in women.