This is a momentous one fourth of milestones for XIAFLEX both commercially and clinically.

June 30 General and administrative expenses for the next one fourth ended, 2014 had been $1.5 million, in comparison to $1.2 million for the same period in 2013. The upsurge in general and administrative expenditures was because of increased legal fees primarily, third party royalty charges and consulting solutions partially offset by reduced professional fees and trader relations. Tax expenses for the next quarter ended June 30, 2014 had been $0.3 million in comparison to $0.5 million for the same period in 2013.Recently, low-power radio rate of recurrence and ultrasound products have been touted as potentially useful in reducing great wrinkling. The unit presumably work by producing heating of the collagen so there is protein denaturation and shrinking sufficiently. This so-called skin tightening appears to produce some cosmetic benefit. If heating system of collagen can be a necessary requirement, special care should be taken up to ensure no burn off injuries occur. The safety and efficacy of the products remains to be demonstrated.