Her medical center switched to phthalate-free feeding systems greater than a 10 years ago. Lyman said she’d noticed fewer liver problems in IV-fed infants since that time, and that the scholarly research makes her wonder if the switch might have contributed.. Chemical Linked to Preemie Liver Woes A chemical found in many plastic products and already under scrutiny for potential health risks is suspected of raising the chance of liver problems in premature infants, according to a new study. The small research in a German medical center suggests a chemical known as a phthalate, used in some intravenous feeding tubing and bags, may raise preemies’ possibilities for liver damage.The U.S. Meals and Medication Administration has agreed to Amicus’ proposal for the Stage 1 research and subsequently transformed the scientific hold of AT2220 to a partial hold to allow the conduct of this study. In 2008 June, the business announced the commencement of a Phase 2 clinical trial of AT2220 in adults with Pompe disease based on data from both preclinical and Stage 1 studies. In February 2009, the business announced it had suspended enrollment after two patients enrolled in the trial experienced critical adverse events which were probably linked to treatment with AT2220.